Sample Articles Directory Kiribati: September 2016

Thursday, September 29, 2016

Bromalex

Bromalex may be available in the countries listed below.

Ingredient matches for Bromalex

Bromazepam

Bromazepam is reported as an ingredient of Bromalex in the following countries:

Portugal

International Drug Name Search

Wednesday, September 28, 2016

Commonly used brand name(s)

In the U.S.

Absorbine Jr. Antifungal

Aftate

Blis-To-Sol

Dermasept Antifungal

Fungi-Guard

Podactin

Q-Naftate

Tinactin

Tinaderm

Ting

In Canada

Athlete's Foot Gel

Dr. Scholl's Athlete's Foot

Pitrex

Scholl's Athlete's Foot Spray

Scholl Tritin Antifungal Powder

Scholl Tritin Antifungal Spray Powder

Tinactin Aerosol Liquid

Tinactin Aerosol Powder

Tinactin Jock Itch

Tinactin Plus

Tinactin Plus Aerosol Powder

Available Dosage Forms:

Ointment

Spray

Cream

Lotion

Gel/Jelly

Powder

Solution

Therapeutic Class: Antifungal

Uses For tolnaftate

Tolnaftate belongs to the group of medicines called antifungals. It is used to treat some types of fungus infections. It may also be used together with medicines taken by mouth for fungus infections.

Tolnaftate is available without a prescription.

Before Using tolnaftate

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For tolnaftate, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to tolnaftate or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Tolnaftate should not be used on children up to 2 years of age, unless otherwise directed by your doctor. Although there is no specific information comparing use of tolnaftate in children 2 years of age and older with use in other age groups, tolnaftate is not expected to cause different side effects or problems in children 2 years of age and older than it does in adults.

Geriatric

Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of tolnaftate in the elderly with use in other age groups.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of tolnaftate

Before applying tolnaftate, wash the affected area and dry thoroughly. Then apply enough medicine to cover the affected area.

Keep tolnaftate away from the eyes.

For patients using the powder form of tolnaftate:

If the powder is used on the feet, sprinkle it between toes, on feet, and in socks and shoes.

For patients using the aerosol powder form of tolnaftate:

Shake well before using.

From a distance of 6 to 10 inches, spray the powder on the affected areas. If it is used on the feet, spray it between toes, on feet, and in socks and shoes.

Do not inhale the powder.

Do not use near heat, near open flame, or while smoking.

For patients using the solution form of tolnaftate:

If tolnaftate solution becomes a solid, it may be dissolved by warming the closed container of medicine in warm water.

For patients using the aerosol solution form of tolnaftate:

Shake well before using.

From a distance of 6 inches, spray the solution on the affected areas. If it is used on the feet, spray between toes and on feet.

Do not inhale the vapors from the spray.

Do not use near heat, near open flame, or while smoking.

To help clear up your infection completely, keep using tolnaftate for 2 weeks after burning, itching, or other symptoms have disappeared , unless otherwise directed by your doctor. Do not miss any doses.

Dosing

The dose of tolnaftate will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of tolnaftate. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For topical dosage forms (aerosol powder, aerosol solution, cream, gel, powder, or topical solution):
- For fungus infections:
  - Adults and children 2 years of age and over—Apply to the affected area(s) of the skin two times a day.
  - Children up to 2 years of age—Use is not recommended except under the advice and supervision of your doctor.

Missed Dose

If you miss a dose of tolnaftate, apply it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Store the canister at room temperature, away from heat and direct light. Do not freeze. Do not keep tolnaftate inside a car where it could be exposed to extreme heat or cold. Do not poke holes in the canister or throw it into a fire, even if the canister is empty.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Precautions While Using tolnaftate

If your skin problem does not improve within 4 weeks, or if it becomes worse, check with your health care professional.

To help prevent reinfection after the period of treatment with tolnaftate, the powder or spray powder form of tolnaftate may be used each day after bathing and carefully drying the affected area.

tolnaftate Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Skin irritation not present before use of tolnaftate

When you apply the aerosol solution form of tolnaftate, a mild temporary stinging may be expected.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: tolnaftate Topical side effects (in more detail)

The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.

The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.

Compare tolnaftate Topical with other medications

Tinea Corporis
Tinea Cruris
Tinea Pedis
Tinea Versicolor

Livifem

Livifem may be available in the countries listed below.

Ingredient matches for Livifem

Tibolone

Tibolone is reported as an ingredient of Livifem in the following countries:

South Africa

International Drug Name Search

tocilizumab Intravenous

toe-si-LIZ-oo-mab

Intravenous route(Solution)

Patients treated with tocilizumab are at increased risk for infections, some progressing to serious infections leading to hospitalization or death. These infections have included bacterial sepsis, tuberculosis, and invasive fungal and other opportunistic infections. Evaluate for latent tuberculosis and treat if necessary prior to initiation of therapy. Monitor patients receiving tocilizumab for signs and symptoms of infection, including tuberculosis, even if initial latent tuberculosis test is negative .

Commonly used brand name(s)

In the U.S.

Actemra

Available Dosage Forms:

Solution

Therapeutic Class: Immunological Agent

Pharmacologic Class: Monoclonal Antibody

Uses For tocilizumab

Tocilizumab injection is a monoclonal antibody. It is used alone or together with other medicines to reduce the signs and symptoms of moderate to severe rheumatoid arthritis. Tocilizumab helps keep joint damage from getting worse after other medicines (e.g., adalimumab, etanercept, infliximab) have been used and did not work well.

Tocilizumab injection is also used to treat systemic juvenile idiopathic arthritis (SJIA) in children 2 years of age and older.

tocilizumab is available only with your doctor's prescription.

Before Using tocilizumab

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For tocilizumab, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to tocilizumab or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of tocilizumab injection in children with SJIA. However, safety and efficacy have not been established in children younger than 2 years of age.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of tocilizumab injection in the elderly. However, elderly patients are more likely to have serious infections, which may require caution in patients receiving tocilizumab injection.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving tocilizumab, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using tocilizumab with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Infliximab

Interactions with Food/Tobacco/Alcohol

Proper Use of tocilizumab

A nurse or other trained health professional will give you tocilizumab. tocilizumab is given through a needle placed in one of your veins. tocilizumab must be given slowly, so the needle will remain in place for at least one hour.

tocilizumab should come with a Medication Guide. It is very important that you read and understand this information. Be sure to ask your doctor about anything you do not understand.

Precautions While Using tocilizumab

It is very important that your doctor check your or your child's progress at regular visits to make sure that tocilizumab is working properly. Blood tests may be needed to check for unwanted effects.

Tell your doctor if you are pregnant or if you plan to become pregnant. If you become pregnant while receiving tocilizumab, your doctor may want you to join a registry for pregnant patients.

You will need to have a skin test for tuberculosis before you or your child start using tocilizumab. Tell your doctor if you or anyone in your home has ever had a positive reaction to a tuberculosis skin test.

tocilizumab may increase your risk of developing infections. Avoid being near people who are sick or have infections while you or your child are using tocilizumab. Wash your hands often. Tell your doctor if you have any kind of infection before you start using tocilizumab. Also tell your doctor if you have ever had an infection that would not go away or an infection that kept coming back.

Using tocilizumab may increase your risk of having certain cancers. Talk to your doctor if you or your child have concerns about this risk.

Call your doctor right away if you or your child start to have a cough that won't go away, weight loss, night sweats, fever, chills, or flu-like symptoms, such as a runny or stuffy nose, headache, blurred vision, or feeling generally ill. These may be signs that you have an infection.

Tocilizumab may cause headaches and skin reactions, such as a rash or itching, while you are receiving the injection or within 24 hours after you receive it. Check with your doctor or nurse right away if you or your child have any of these symptoms.

tocilizumab may cause a serious type of allergic reaction called anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you or your child have a rash; hives; itching; swelling of the face, tongue, and throat; trouble breathing; or chest pain after you receive the medicine.

tocilizumab may cause serious stomach and bowel problems, especially if you have a history of ulcers or diverticulosis. Check with your doctor right away if you or your child start having severe stomach cramps or pain; black, tarry stools; diarrhea; fever; or vomiting that is severe and sometimes bloody while being treated with tocilizumab.

While you or your child are being treated with tocilizumab, and after you stop treatment, do not have any immunizations (vaccines) without your doctor's approval. Tocilizumab may lower your body's resistance, and there is a chance you might get the infection the immunization is meant to prevent. In addition, other persons living in your household should not get live vaccines (e.g., nasal flu virus vaccine). Try to avoid being around persons who have received live vaccines. Do not get close to them and do not stay in the same room with them for very long. If you or your child cannot take these precautions, you should wear a protective face mask that covers the nose and mouth. Talk to your doctor if you have questions about this.

Your child's vaccines need to be current before he or she begins using tocilizumab injection. Be sure to ask your child's doctor if you have any questions about this.

tocilizumab may increase the level of cholesterol and fats in your blood. If this condition occurs, your doctor may give you a medicine to lower the cholesterol and fats. Talk to your doctor if you or your child have concerns.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

tocilizumab Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Abdominal or stomach pain

black, tarry stools

bloody or cloudy urine

blurred vision

body aches or pain

chest pain

cough

cough producing mucus

diarrhea

difficult, burning, or painful urination

difficulty with breathing

difficulty with swallowing

dizziness

ear congestion

fast heartbeat

feeling of warmth

fever or chills

frequent urge to urinate

headache

hives

itching

loss of appetite

loss of consciousness

loss of voice

lower back or side pain

nasal congestion

nausea

nervousness

pain or tenderness around the eyes and cheekbones

painful blisters on the trunk of the body

pale skin

pounding in the ears

puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue

redness of the face, neck, arms, and occasionally, upper chest

shortness of breath or troubled breathing

skin rash

slow or fast heartbeat

sneezing

sore throat

stuffy or runny nose

sudden sweating

tightness of the chest or wheezing

troubled breathing

ulcers, sores, or white spots in the mouth

unusual bleeding or bruising

unusual tiredness or weakness

weakness

Less common

Bladder pain

blurred vision

burning feeling in the chest or stomach

confusion

dark urine

decrease in height

difficulty with moving

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

fast, irregular, pounding, or racing heartbeat or pulse

feeling hot

frequent urge to urinate

general feeling of discomfort or illness

heartburn

indigestion

itching, pain, redness, swelling, tenderness, or warmth on the skin at the injection site

joint pain

light-colored stools

muscle aches and pains

muscle cramps or stiffness

pain in the back, ribs, arms, or legs

pain in the groin or genitals

pale skin

severe stomach pain

sharp back pain just below the ribs

shivering

stomach upset

sweating

swelling

swollen joints

swollen, painful, or tender lymph glands in the face, neck, armpit, or groin

tenderness in the stomach area

trouble with sleeping

troubled breathing with exertion

unexplained runny nose or sneezing

upper right abdominal or stomach pain

vomiting

yellow eyes and skin

Rare

Acid or sour stomach

belching

changes in skin color

confusion

coughing or spitting up blood

fainting

gaseous abdominal or stomach pain

lightheadedness

neck pain

night sweats

noisy breathing

pain

pain, swelling, or redness in the joints

rapid, shallow breathing

recurrent fever

red, tender, or oozing skin at incision

stomach bloating, burning, cramping, or pain

sudden high fever or low-grade fever for months

swelling of the foot or leg

swollen lymph nodes

weight loss

Incidence not known

Dilated neck veins

extreme fatigue

severe abdominal or stomach pain, cramping, or burning

swelling of the face, fingers, feet, or lower legs

vomiting of material that looks like coffee grounds, severe and continuing

weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Burning, dry, or itching eyes

constipation

discharge, excessive tearing

redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

skin rash, encrusted, scaly and oozing

swelling or inflammation of the mouth

warmth on the skin

Less common

Abnormal or decreased touch sensation

accumulation of pus

back pain

bleeding gums

blemishes on the skin

bloody eye

chapped, red, or swollen lips

earache

feeling of constant movement of self or surroundings

hives or welts

irritation in the mouth

loose teeth

persistent breath odor or bad taste in your mouth

pimples

redness and swelling of the gums

redness of the eye

redness of the skin

redness or swelling in the ear

scaling, redness, burning, pain, or other signs of inflammation of the lips

sensation of spinning

sleeplessness

sore mouth or tongue

sores on the skin

stomach soreness or discomfort

swollen, red, or tender area of infection

unable to sleep

white patches in the mouth or on the tongue

Rare

Bleeding after defecation

blindness

bloody nose

burning, numbness, tingling, or painful sensations

change in hearing

continuing ringing or buzzing or other unexplained noise in the ears

coughing or spitting up blood

decreased vision or other changes in vision

dry mouth

ear drainage

earache

flushed, dry skin

fruit-like breath odor

hearing loss

increased hunger

increased thirst

increased urination

itching ears

loss of consciousness

redness, swelling, or soreness of the tongue

thirst

uncomfortable swelling around the anus

unexplained weight loss

unsteadiness or awkwardness

weakness in the arms, hands, legs, or feet

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: tocilizumab Intravenous side effects (in more detail)

More tocilizumab Intravenous resources

Tocilizumab Intravenous Side Effects (in more detail)
Tocilizumab Intravenous Use in Pregnancy & Breastfeeding
Tocilizumab Intravenous Drug Interactions
Tocilizumab Intravenous Support Group
0 Reviews for Tocilizumab Intravenous - Add your own review/rating

Compare tocilizumab Intravenous with other medications

Juvenile Idiopathic Arthritis
Rheumatoid Arthritis

Raserpril

Raserpril may be available in the countries listed below.

Ingredient matches for Raserpril

Enalapril

Enalapril maleate (a derivative of Enalapril) is reported as an ingredient of Raserpril in the following countries:

Ecuador

International Drug Name Search

Tussi-12 S Suspension

Pronunciation: car-beta-PEN-tane/klor-fen-EER-a-meen
Generic Name: Carbetapentane/Chlorpheniramine
Brand Name: Examples include Tannic-12 S and Tussi-12 S

Tussi-12 S Suspension is used for:

Relieving symptoms of sinus congestion, runny nose, sneezing, and cough due to colds, upper respiratory infections, and allergies. It may also be used for other conditions as determined by your doctor.

Tussi-12 S Suspension is an antihistamine and cough suppressant combination. The antihistamine works by blocking the action of histamine, which helps reduce symptoms, such as watery eyes and sneezing. The cough suppressant works in the brain to help decrease the cough reflex to reduce a dry cough.

Do NOT use Tussi-12 S Suspension if:

you are allergic to any ingredient in Tussi-12 S Suspension

you are unable to urinate or are having an asthma attack

you take sodium oxybate (GHB) or you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the last 14 days

Contact your doctor or health care provider right away if any of these apply to you.

Before using Tussi-12 S Suspension:

Some medical conditions may interact with Tussi-12 S Suspension. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a fast, slow, or irregular heartbeat or a history of heart problems

if you have a history of high blood pressure; diabetes; heart blood vessel problems; stroke; glaucoma; a blockage of your bladder, stomach, or intestines; ulcers; trouble urinating; an enlarged prostate or other prostate problems; seizures; or an overactive thyroid

if you have a history of asthma, chronic cough, lung problems (eg, chronic bronchitis, emphysema), or chronic obstructive pulmonary disease (COPD), or if your cough occurs with large amounts of mucus

Some MEDICINES MAY INTERACT with Tussi-12 S Suspension. Tell your health care provider if you are taking any other medicines, especially any of the following:

Furazolidone, MAO inhibitors (eg, phenelzine), sodium oxybate (GHB), or tricyclic antidepressants (eg, amitriptyline) because side effects of Tussi-12 S Suspension may be increased

Hydantoins (eg, phenytoin) because side effects may be increased by Tussi-12 S Suspension

This may not be a complete list of all interactions that may occur. Ask your health care provider if Tussi-12 S Suspension may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Tussi-12 S Suspension:

Use Tussi-12 S Suspension as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Tussi-12 S Suspension may be taken with or without food.

Shake well before using.

Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.

If you miss a dose of Tussi-12 S Suspension, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Tussi-12 S Suspension.

Important safety information:

Tussi-12 S Suspension may cause dizziness, drowsiness, or blurred vision. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Tussi-12 S Suspension. Using Tussi-12 S Suspension alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.

Do not take diet or appetite control medicines while you are taking Tussi-12 S Suspension without checking with your doctor.

Tussi-12 S Suspension contains chlorpheniramine. Before you begin taking any new prescription or nonprescription medicine, read the ingredients to see if it also contains chlorpheniramine. If it does or if you are uncertain, contact your doctor or pharmacist.

Do NOT exceed the recommended dose or take Tussi-12 S Suspension for longer than prescribed without checking with your doctor.

If your symptoms do not improve within 5 to 7 days or if they become worse, check with your doctor.

Tussi-12 S Suspension may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to Tussi-12 S Suspension. Use a sunscreen or protective clothing if you must be outside for a prolonged period.

If you are scheduled for allergy skin testing, do not take Tussi-12 S Suspension for several days before the test because it may decrease your response to the skin tests.

Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using Tussi-12 S Suspension.

Use Tussi-12 S Suspension with caution in the ELDERLY because they may be more sensitive to its effects.

Caution is advised when using Tussi-12 S Suspension in CHILDREN because they may be more sensitive to its effects.

PREGNANCY and BREAST-FEEDING: If you become pregnant while taking Tussi-12 S Suspension, discuss with your doctor the benefits and risks of using Tussi-12 S Suspension during pregnancy. It is unknown if Tussi-12 S Suspension is excreted in breast milk. Do not breast-feed while taking Tussi-12 S Suspension.

Possible side effects of Tussi-12 S Suspension:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; excitability; headache; loss of appetite; nausea; nervousness or anxiety; trouble sleeping; upset stomach; vomiting; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); difficulty urinating or inability to urinate; fast or irregular heartbeat; hallucinations; seizures; severe dizziness, lightheadedness, or headache; tremor; trouble sleeping; vision changes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

See also: Tussi-12 S side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include blurred vision; confusion; hallucinations; seizures; severe dizziness, lightheadedness, or headache; severe drowsiness; unusually fast, slow, or irregular heartbeat; vomiting.

Proper storage of Tussi-12 S Suspension:

Store Tussi-12 S Suspension at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Tussi-12 S Suspension out of the reach of children and away from pets.

General information:

If you have any questions about Tussi-12 S Suspension, please talk with your doctor, pharmacist, or other health care provider.

Tussi-12 S Suspension is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Tussi-12 S Suspension. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Tussi-12 S resources

Tussi-12 S Side Effects (in more detail)
Tussi-12 S Use in Pregnancy & Breastfeeding
Tussi-12 S Drug Interactions
Tussi-12 S Support Group
0 Reviews for Tussi-12 S - Add your own review/rating

Compare Tussi-12 S with other medications

Cold Symptoms

Fluoresceine Oxybuprocaine Faure

Fluoresceine Oxybuprocaine Faure may be available in the countries listed below.

Ingredient matches for Fluoresceine Oxybuprocaine Faure

Fluorescein

Fluorescein sodium (a derivative of Fluorescein) is reported as an ingredient of Fluoresceine Oxybuprocaine Faure in the following countries:

Switzerland

Oxybuprocaine

Oxybuprocaine hydrochloride (a derivative of Oxybuprocaine) is reported as an ingredient of Fluoresceine Oxybuprocaine Faure in the following countries:

Switzerland

International Drug Name Search

Lamogine

Lamogine may be available in the countries listed below.

Ingredient matches for Lamogine

Lamotrigine

Lamotrigine is reported as an ingredient of Lamogine in the following countries:

Australia

Czech Republic

Israel

International Drug Name Search

Bicalutamide

Class: Antineoplastic Agents
VA Class: AN900
Chemical Name: (±) - N - [4 - cyano - 3 - (trifluoromethyl)phenyl] - 3 - [(4 - fluorophenyl)sulfonyl] - 2 - hydroxy - 2 - methylpropanamide
Molecular Formula: C₁₈H₁₄F₄N₂O₄S
CAS Number: 90357-06-5
Brands: Casodex

Introduction

Antineoplastic agent; a nonsteroidal antiandrogen.¹ ³ ⁴ ¹⁴ ⁴⁰ ⁴³

Uses for Bicalutamide

Prostate Cancer

Palliative treatment of metastatic (stage D2) prostate cancer; should be used in conjunction with a luteinizing hormone-releasing hormone (LHRH) analog (e.g., goserelin, leuprolide acetate).¹ ² ³ ⁹ ¹⁸

Bicalutamide Dosage and Administration

General

Initiate bicalutamide and LHRH analog concomitantly.¹ ³⁵ ⁴³

Administration

Oral Administration

Administer orally once daily at the same time each day (morning or evening) without regard to meals.¹ ³⁵ ⁴³

Dosage

Adults

Prostate Cancer

Oral

50 mg once daily.¹ ³ ⁹ ⁴⁰ ⁴³ Duration of combined therapy with LHRH analog depends on clinical response.³⁵

Cautions for Bicalutamide

Contraindications

Known hypersensitivity to bicalutamide or any ingredient in the formulation.¹

Should not be used in women, particularly for conditions that are not serious or life-threatening.¹

Women who are or may become pregnant.¹ (See Fetal/Neonatal Morbidity and Mortality under Cautions.)

Warnings/Precautions

Warnings

Fetal/Neonatal Morbidity and Mortality

May cause fetal harm; contraindicated in pregnant women.¹

If used during pregnancy or if patient becomes pregnant, apprise of potential fetal hazard.¹

Hepatic Effects

Severe liver injury reported, sometimes resulting in hospitalization and/or death;¹ ²⁶ manifestations generally occurred within first 3–4 months.¹

Possible hepatitis or marked increases in serum concentrations of hepatic transaminases.¹

Measure serum transaminase concentrations prior to initiation of therapy, at regular intervals during the first 4 months, and periodically thereafter.¹

Immediately measure serum transaminase (especially ALT) concentrations if manifestations suggestive of liver dysfunction occur.¹

Immediately discontinue if jaundice develops or serum ALT concentration is >2 times ULN; monitor liver function closely thereafter.¹

General Precautions

PSA Monitoring

Regularly monitor serum PSA to assess response; if PSA increases, evaluate for possible disease progression.¹ ¹⁷

For patients with objective progression of disease and elevated serum PSA, consider temporarily withdrawing bicalutamide while continuing LHRH analog.¹ ³⁵ ³⁶ ³⁷ Withdrawal of bicalutamide may be associated with PSA decrease.³¹ ⁴⁴

Possible Prescribing and Dispensing Errors

Ensure accuracy of prescription; similarity in spelling of Casodex (the trade name for bicalutamide) and Kapidex (former trade name for dexlansoprazole, a proton-pump inhibitor) may result in errors.²¹⁷ ²¹⁸ ²¹⁹ ²²³

Specific Populations

Pregnancy

Category X.¹ (See Fetal/Neonatal Morbidity and Mortality and also Contraindications under Cautions.)

Lactation

Not known whether bicalutamide is distributed into milk;¹ use caution.¹

Pediatric Use

Safety and efficacy not established.¹

Hepatic Impairment

Use with caution in patients with moderate to severe hepatic impairment.¹ ³

Consider periodic liver function tests in patients with hepatic impairment receiving long-term therapy.¹ ³⁵

Women

Not intended for use in women, particularly for nonserious or nonlife-threatening conditions.¹

Common Adverse Effects

Combined therapy with LHRH analog: hot flashes, pain (including abdominal, back, and pelvic pain), asthenia, constipation, infection, nausea, dyspnea, diarrhea.¹

Gynecomastia and breast pain frequent if bicalutamide used as monotherapy.¹

Interactions for Bicalutamide

Does not induce CYP isoenzymes.¹ Pharmacokinetic interaction unlikely with drugs metabolized by CYP isoenzymes.¹

Specific Drugs

Drug	Interaction	Comments
Alcohol	Increased risk of facial flushing⁴¹	Avoid alcohol consumption during therapy⁴¹
LHRH analog (e.g., goserelin, leuprolide)	Pharmacokinetic interaction unlikely¹
Warfarin and other coumarins	Decreased anticoagulant protein binding and increased plasma concentrations; increased anticoagulant effects¹	Monitor PT; adjust anticoagulant dosage as needed¹

Bicalutamide Pharmacokinetics

Absorption

Bioavailability

Well-absorbed following oral administration; absolute bioavailability is unknown.¹

Food

Food has no clinically important effect on rate or extent of absorption.¹

Distribution

Plasma Protein Binding

96%.¹

Elimination

Metabolism

Undergoes stereospecific metabolism in the liver.¹

Active R-enantiomer is predominantly oxidized to an inactive metabolite followed by glucuronidation.¹ Inactive S-enantiomer is principally metabolized by glucuronidation.¹

S-enantiomer is rapidly cleared relative to the R-enantiomer; R-enantiomer accounts for about 99% of total steady-state plasma concentrations.¹

Elimination Route

Both parent and metabolite glucuronides are eliminated in urine and feces.¹

Half-life

Approximately 6 days.¹

Special Populations

Half-life of R-enantiomer was increased approximately 76% in patients with severe hepatic impairment.¹

Stability

Storage

Oral

Tablets

20–25°C.¹

ActionsActions

A selective antiandrogen with no androgenic or progestational activity in various animal models.¹² ¹⁷ ⁴³

Competitively blocks nuclear androgen receptors in target tissues (e.g., adrenal cortex, prostate, seminal vesicles).¹ ¹¹ ¹² ¹⁴ ¹⁶ ³⁴ ⁴³

Blockade of androgen receptors in the hormone-sensitive tumor cells may result in growth arrest or transient tumor regression through inhibition of androgen-dependent DNA and protein synthesis.¹ ¹¹ ¹² ¹⁴ ¹⁶ ³⁴ ⁴³

Inhibits initial androgenic stimulation and potential exacerbation of symptoms (e.g., bone pain, urinary obstruction, liver pain, impending spinal cord compression) associated with the first month of LHRH analog therapy.⁸ ¹⁰ ¹⁴ ¹⁶ ¹⁸ ²¹ ²³ ²⁵ ⁴⁰

Advice to Patients

Risk of potential liver toxicity.¹

Risk of facial flushing,¹ ⁴¹ particularly if used in conjunction with alcohol.⁴¹ Avoidance of alcohol recommended if flushing occurs.⁴¹

Importance of initiating bicalutamide concomitantly with LHRH analog and of not interrupting or discontinuing therapy without consulting a clinician.¹

If used in women, importance of women informing their clinician if they are or plan to become pregnant or plan to breast-feed.¹

Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs, as well as concomitant illnesses.¹

Importance of informing patients of other important precautionary information.¹ (See Cautions.)

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Bicalutamide
Routes	Dosage Forms	Strengths	Brand Names	Manufacturer
Oral	Tablets, film- coated	50 mg	Casodex	AstraZeneca

Comparative Pricing

This pricing information is subject to change at the sole discretion of DS Pharmacy. This pricing information was updated 03/2011. Actual costs to patients will vary depending on the use of specific retail or mail-order locations and health insurance copays.

Bicalutamide 50MG Tablets (TEVA PHARMACEUTICALS USA): 30/$59.99 or 90/$159.97

Casodex 50MG Tablets (ASTRAZENECA): 30/$536.99 or 90/$1608.02

Disclaimer

This report on medications is for your information only, and is not considered individual patient advice. Because of the changing nature of drug information, please consult your physician or pharmacist about specific clinical use.

The American Society of Health-System Pharmacists, Inc. and Drugs.com represent that the information provided hereunder was formulated with a reasonable standard of care, and in conformity with professional standards in the field. The American Society of Health-System Pharmacists, Inc. and Drugs.com make no representations or warranties, express or implied, including, but not limited to, any implied warranty of merchantability and/or fitness for a particular purpose, with respect to such information and specifically disclaims all such warranties. Users are advised that decisions regarding drug therapy are complex medical decisions requiring the independent, informed decision of an appropriate health care professional, and the information is provided for informational purposes only. The entire monograph for a drug should be reviewed for a thorough understanding of the drug's actions, uses and side effects. The American Society of Health-System Pharmacists, Inc. and Drugs.com do not endorse or recommend the use of any drug. The information is not a substitute for medical care.

AHFS Drug Information. © Copyright, 1959-2011, Selected Revisions August 2010. American Society of Health-System Pharmacists, Inc., 7272 Wisconsin Avenue, Bethesda, Maryland 20814.

References

1. AstraZeneca. Casodex (bicalutamide) tablets prescribing information. Wilmington, DE; 2002 Sep.

2. Anon. Drugs of choice for cancer chemotherapy. Med Lett Drugs Ther. 2000; 42: 83-92.

3. Blackledge G. Casodexmechanisms of action and opportunities for usage. Cancer. 1993; 72(Suppl):3830-3. [IDIS 323230] [PubMed 7504578]

4. Cockshott ID, Sotaniemi EA, Cooper KJ et al. The pharmacokinetics of Casodex enantiomers in subjects with impaired liver function. Br J Clin Pharmacol. 1993; 36:339-43. [IDIS 321958] [PubMed 12959312]

5. Wilson JD. Androgens. In: Gilman AG, Rall TW, Nies AS et al, eds. Goodman and Gilman’s the pharmacological basis of therapeutics. 8th ed. New York: Pergamon Press; 1990:1413-1430.

6. Prostate cancer. From: CancerNet/PDQ. Physician data query (database). Bethesda, MD: National Cancer Institute; 2001 Oct.

7. Schering. Eulexin (flutamide) capsules prescribing information (dated 1994 Jul). In: Physicians’ desk reference. 49th ed. Montvale, NJ: Medical Economics Company Inc; 1995:2253-4.

8. Crawford ED, Eisenberger MA, McLeod DG et al. A controlled trial of leuprolide with and without flutamide in prostatic carcinoma. N Engl J Med. 1989; 321:419-24. [IDIS 258377] [PubMed 2503724]

9. Schellhammer P, Sharifi R, Block N et al et al. A controlled trial of bicalutamide versus flutamide, each in combination with luteinizing hormone-releasing hormone analogue therapy, in patients with advanced prostate cancer. Urology. 1995; 45:745-52. [PubMed 7538237]

10. Dole EJ, Holdsworth MT. Nilutamide: an anitandrogen for the treatment of prostate cancer. Ann Pharmacother. 1997; 31: 65-75.

11. Geller J. Basis for hormonal management of advanced prostate cancer. Cancer. 1993; 71(Suppl):1039-45. [IDIS 313140] [PubMed 7679038]

12. McLeod DG. Antiandrogenic drugs. Cancer. 1993; 71(Suppl):1046-9. [IDIS 313141] [PubMed 8428326]

13. Migliari R, Muscas G, Usai E. Effect of Casodex on sleep-related erections in patients with advanced prostate cancer. J Urol. 1992; 148:338-41. [IDIS 300700] [PubMed 1378907]

14. Denis L. Prostate cancer: primary hormonal treatment. Cancer. 1993; 71(Suppl):1050-8. [IDIS 313142] [PubMed 8428327]

15. Smith PH. Deferred therapy in patients with advanced disease. Cancer. 1993; 71(Suppl):1074-7. [IDIS 313144] [PubMed 8428330]

16. Daneshgari F, Crawford ED. Endocrine therapy of advanced carcinoma of the prostate. Cancer. 1993; 71(Suppl):1089-97. [IDIS 313146] [PubMed 8428333]

17. Soloway MS, Matzkin H. Antiandrogenic agents as monotherapy in advanced prostatic carcinoma. Cancer. 1993; 71(Suppl):1083-8. [IDIS 313145] [PubMed 8428332]

18. Mahler C. Is disease flare a problem? Cancer. 1993; 72(Suppl):3799-802. (IDIS 323226)

19. Sagalowsky AI, Wilson JD. Hyperplasia and carcinoma of the prostate. In: Wilson JD, Braunwald E, Isselbacher KJ et al, eds. Harrison’s principles of internal medicine. 12th ed. New York: McGraw-Hill Company; 1991: 1629-33.

20. Brendler CB. Diseases of the prostate. In: Wyngaarden JB, Smith LH Jr, Bennett JC, eds. Cecil textbook of medicine. 19th ed. Philadelphia: WB Saunders Company; 1992:1351-5.

21. Chrisp P, Goa KL. Goserelin: a review of its pharmacodynamic and pharmacokinetic properties, and clinical use in sex hormone-related conditions. Drugs. 1991; 41:254-88. [PubMed 1709853]

22. Vogelzang NJ, Kennealey GT. Recent developments in endocrine treatment of prostate cancer. Cancer. 1992; 70:966-76. [IDIS 300575] [PubMed 1386283]

23. Santen RJ. Endocrine treatment of prostate cancer. J Clin Endocrinol Metab. 1992; 75:685-9. [IDIS 302863] [PubMed 1517354]

24. Tyrrell CJ, Altwein JE, Klippel F et al et al. A multicenter randomized trial comparing the luteinizing hormone-releasing hormone analogue goserelin acetate alone and with flutamide in the treatment of advanced prostate cancer. J Urol. 1991; 146:1321-6. [IDIS 290344] [PubMed 1834864]

25. Kuhn JM, Billebaud T, Navratil H et al. Prevention of a gonadotropin-releasing hormone analogue (buserelin) in metastatic prostatic carcinoma by administration of an antiandrogen (nilutamide). N Engl J Med. 1989; 321:413-8. [IDIS 258376] [PubMed 2503723]

26. Dawson LA, Chow E, Morton G. Fulminant hepatic failure associated with bicalutamide. Urology. 1997; 49:283-4. [PubMed 9037299]

27. Soloway MS. Newer methods of hormonal therapy for prostate cancer. Urology. 1984; 24(Suppl):30-8. [IDIS 198972] [PubMed 6437034]

28. Paulson DF. Management of metastatic prostatic cancer. Urology. 1985; 25:(Suppl):49-52.

29. Tolis G, Ackman D, Stellos A et al. Tumor growth inhibition in patients with prostatic carcinoma treated with luteinizing hormone-releasing hormone agonists. Med Sci. 1982; 79:1658-62.

30. Elder JS, Catalona WJ. Management of newly diagnosed metastatic carcinoma of the prostate. Urol Clin North Am. 1984; 11:283-95. [PubMed 6428022]

31. Nieh PT. Withdrawal phenomenon with the antiandrogen casodex. J Urol. 1995; 153:1070-2. [IDIS 342239] [PubMed 7531785]

32. Crawford ED. Withdrawal phenomenon with the antiandrogen Casodex: editorial comments. J Urol. 1995; 153:1072.

33. Scher HI, Kelly WK. Withdrawal phenomenon with the antiandrogen Casodex: editorial comments. J Urol. 1995; 153:1072-3.

34. Kennealey GT, Furr BJA. Use of the nonsteroidal anti-androgen Casodex in advanced prostatic carcinoma. Urol Clin North Am. 1991; 18:99-110. [PubMed 1992575]

35. Zeneca Pharmaceuticals, Wilmington, DE: Personal communication.

36. Cersosimo RJ, Carr D. Prostate cancer: current and evolving strategies. Am J Health-Syst Pharm. 1996; 53:381-96. [IDIS 360612] [PubMed 8673658]

37. McLeod DG, Kolvenbag GJCM. Defining the role of antiandrogens in the treatment of prostate cancer. Urology. 1996; 47(Suppl 1A):85-9. [PubMed 8560682]

39. Erlichman C, Loprinzi CL. Hormonal therapies. In: DeVita VT Jr, Hellman S, Rosenberg SA, eds. Cancer: principles and practice of oncology. 5th ed. Philadelphia, PA: J. B. Lippincott; 1997:395-405.

40. Anon. Bicalutamide for prostate cancer. Med Lett Drugs Ther. 1996; 38:56-7. [PubMed 8657047]

41. Kirschenbaum A. Management of hormonal treatment effects. Cancer. 1995; 75:1983-6.

42. Schellhammer PF, Sharifi R, Block NL et al. Clinical benefits of bicalutamide compared with flutamide in combined androgen blockade for patients with advanced prostatic carcinoma: final report of a double-blind, randomized, multicenter trial. Casodex Combination Study Group. Urology. 1997; 50:330-6. [PubMed 9301693]

43. Goa KL, Spencer CM. Bicalutamide in advanced prostate cancer: a review. Drugs Aging. 1998; 12:401-22. [PubMed 9606617]

44. Culig Z, Hoish A, Hittmair A et al. Androgen receptor gene mutations in prostate cancer: implications for disease progression and therapy. Drug Aging. 1997; 10:50-8.

217. US Food and Drug Administration. FDA approves name change for heartburn drug Kapidex. Rockville, MD; 2010 Mar 4. News release from FDA website ().

218. Institute for Safe Medication Practices. Kapidex-Casodex confusion. ISMP Medication Safety Alert! Community/Ambulatory Care edition. Horsham, PA; 2009 Jul. From ISMP website ().

219. Institute for Safe Medication Practices. ISMP quarterly action agenda July–September 2009. ISMP Medication Safety Alert! Acute Care edition. Horsham, PA; 2009 Oct 8. From ISMP website ().

222. Takeda Pharmaceuticals America. Dexilant (dexlansoprazole) delayed-release capsules prescribing information. Deerfield, IL; 2010 Mar.

223. Institute for Safe Medication Practices. Progress with preventing name confusion errors. ISMP Medication Safety Alert! Acute Care edition. Horsham, PA; 2007 Aug 9. From ISMP website ().

More Bicalutamide resources

Bicalutamide Side Effects (in more detail)
Bicalutamide Dosage
Bicalutamide Use in Pregnancy & Breastfeeding
Drug Images
Bicalutamide Drug Interactions
Bicalutamide Support Group
5 Reviews for Bicalutamide - Add your own review/rating

Bicalutamide Prescribing Information (FDA)

Bicalutamide MedFacts Consumer Leaflet (Wolters Kluwer)

Bicalutamide Professional Patient Advice (Wolters Kluwer)

bicalutamide Advanced Consumer (Micromedex) - Includes Dosage Information

Casodex Prescribing Information (FDA)

Casodex Consumer Overview

Compare Bicalutamide with other medications

Prostate Cancer

Zolpidemtartraat Losan

Zolpidemtartraat Losan may be available in the countries listed below.

Ingredient matches for Zolpidemtartraat Losan

Zolpidem

Zolpidem tartrate (a derivative of Zolpidem) is reported as an ingredient of Zolpidemtartraat Losan in the following countries:

Netherlands

International Drug Name Search

Tuesday, September 27, 2016

Triprolidine Syrup

Pronunciation: trye-PROE-li-deen
Generic Name: Triprolidine
Brand Name: Zymine

Triprolidine Syrup is used for:

Preventing or treating symptoms of hay fever and other upper respiratory allergies or the common cold, such as runny nose, sneezing, itching of the nose and throat, and itchy, watery eyes, and relieving cough. It may also be used for other conditions as determined by your doctor.

Triprolidine Syrup is an antihistamine. It works by blocking the action of histamine, reducing the symptoms of an allergic reaction.

Do NOT use Triprolidine Syrup if:

you are allergic to any ingredient in Triprolidine Syrup or other similar medicines

you are taking sodium oxybate (GHB)

Contact your doctor or health care provider right away if any of these apply to you.

Before using Triprolidine Syrup:

Some medical conditions may interact with Triprolidine Syrup. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

if you are pregnant, planning to become pregnant, or are breast-feeding

if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement

if you have allergies to medicines, foods, or other substances

if you have a fast, slow, or irregular heartbeat

if you have a history of asthma; chronic obstructive pulmonary disease (COPD); chronic bronchitis; lung problems (eg, emphysema); shortness of breath; sleep apnea; heart blood vessel problems; stroke; seizures; a blockage of your stomach, intestine, or bladder; difficulty urinating; diabetes; ulcers; an enlarged prostate or other prostate problems; glaucoma; heart problems; high blood pressure; porphyria; phenylketonuria; or an overactive thyroid

Some MEDICINES MAY INTERACT with Triprolidine Syrup. Tell your health care provider if you are taking any other medicines, especially any of the following:

Sodium oxybate (GHB) because an increase in sleep duration and a decrease in the ability to breathe are likely to occur

Monoamine oxidase (MAO) inhibitors (eg, phenelzine) because they may increase side effects of Triprolidine Syrup

This may not be a complete list of all interactions that may occur. Ask your health care provider if Triprolidine Syrup may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Triprolidine Syrup:

Use Triprolidine Syrup as directed by your doctor. Check the label on the medicine for exact dosing instructions.

Triprolidine Syrup may be taken with or without food.

Use a measuring device marked for medicine dosing. Ask your pharmacist for help if you are unsure of how to measure your dose.

Use Triprolidine Syrup exactly as directed on the package, unless instructed differently by your doctor. If you are taking Triprolidine Syrup without a prescription, follow any warnings and precautions on the label.

If you miss a dose of Triprolidine Syrup and you are taking it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Triprolidine Syrup.

Important safety information:

Triprolidine Syrup may cause drowsiness or dizziness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Triprolidine Syrup. Using Triprolidine Syrup alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.

Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Triprolidine Syrup. Triprolidine Syrup will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.

Triprolidine Syrup may cause dizziness. Alcohol, hot weather, exercise, and fever can increase this effect. To prevent it, sit up or stand slowly, especially in the morning. Also, sit or lie down at the first sign of dizziness.

Do not become overheated in hot weather or during exercise or other activities since heatstroke may occur.

If you are scheduled for allergy skin testing, do not take Triprolidine Syrup for several days before the test because it may decrease your response to the skin tests.

Phenylketonuria patients - Triprolidine Syrup contains phenylalanine.

If you are using Triprolidine Syrup for cough, cold, or allergy symptoms, stop use and contact your doctor if your symptoms do not improve within 7 days or are accompanied by fever.

Use Triprolidine Syrup with caution in the ELDERLY because they may be more sensitive to its effects, especially dizziness, sedation, and lightheadedness upon standing.

Safe use and instructions for use in CHILDREN differs according to the brand used. Talk to your doctor or pharmacist if you have any questions about the brand you are using.

PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using Triprolidine Syrup during pregnancy. Triprolidine Syrup is excreted in breast milk. If you are or will be breast-feeding while you are using Triprolidine Syrup, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Triprolidine Syrup:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Dizziness; drowsiness; dry mouth, throat, and nose; excitability; thickening of mucus in nose or throat.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); convulsions; fast heartbeat or pounding in the chest; decreased alertness; hallucinations; tremor; wheezing.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch .

See also: Triprolidine side effects (in more detail)

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include coma; excitement; hallucinations; loss of consciousness; muscle twitching; seizures; tremor; weakness.

Proper storage of Triprolidine Syrup:

Store Triprolidine Syrup at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Triprolidine Syrup out of the reach of children and away from pets.

General information:

If you have any questions about Triprolidine Syrup, please talk with your doctor, pharmacist, or other health care provider.

Triprolidine Syrup is to be used only by the patient for whom it is prescribed. Do not share it with other people.

If your symptoms do not improve or if they become worse, check with your doctor.

Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Triprolidine Syrup. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: February 1, 2012

Database Edition 12.1.1.002

More Triprolidine resources

Triprolidine Side Effects (in more detail)
Triprolidine Use in Pregnancy & Breastfeeding
Triprolidine Drug Interactions
Triprolidine Support Group
1 Review for Triprolidine - Add your own review/rating

Compare Triprolidine with other medications

Allergic Urticaria
Allergies
Conjunctivitis, Allergic
Eye Redness/Itching
Hay Fever
Rhinorrhea

Teat Dip HP 5

Dosage Form: FOR ANIMAL USE ONLY

FOR COMMERCIAL USE ONLY

KEEP OUT OF REACH OF CHILDREN

NOT FOR HUMAN USE

CAUTION

Harmful if swallowed, eye irritant.

FIRST AID :

Avoid contact with skin and eyes. Contact can cause severe irritation. Get medical attention. If ingested, drink large amounts of water or milk. DO NOT induce vomiting. Get immediate attention. Avoid repeated contact with skin and hands. Use rubber gloves to avoid skin irritation. If contact occurs, wash thoroughly with clean water.

EMERGENCY : CHEMTREC 800-424-9300

Prior to milking, dip teats in undiluted Teat Dip HP 5. Wipe off with a clean towel after 15-30 seconds. After milking reapply Teat Dip HP 5. Do not rinse or wash off. Allow teats to dry before letting cows outdoors in cold weather to guard against.

PRINCIPAL DISPLAY PANEL/REPRESENTATIVE LABEL

Teat Dip HP 5

Non-Iodine Teat Dip

An Aid Reducing the Spread of Organisms

Which May Cause Mastitis

ACTIVE INGREDIENTS:

Hydrogen Peroxide........................0.5%

INACTIVE INGREDIENTS............99.5%

Wausau Chemical Corporation

2001 North River Drive

Wausau, WI 54403-0953 U.S.A.

Teat Dip HP 5
hydrogen peroxide solution

Product Information
Product Type	OTC ANIMAL DRUG	NDC Product Code (Source)	64892-006
Route of Administration	TOPICAL	DEA Schedule

Active Ingredient/Active Moiety
Ingredient Name	Basis of Strength	Strength
Hydrogen Peroxide (Hydrogen Peroxide)	Hydrogen Peroxide	0.5 L in 100 L

Inactive Ingredients
Ingredient Name	Strength
No Inactive Ingredients Found

Product Characteristics
Color		Score
Shape		Size
Flavor		Imprint Code
Contains

Packaging
#	NDC	Package Description	Multilevel Packaging
1	64892-006-16	18.9 L In 1 DRUM	None
2	64892-006-17	56.78 L In 1 DRUM	None
3	64892-006-18	113.6 L In 1 DRUM	None
4	64892-006-21	208.2 L In 1 DRUM	None
5	64892-006-88	1040 L In 1 CONTAINER	None

Marketing Information
Marketing Category	Application Number or Monograph Citation	Marketing Start Date	Marketing End Date
unapproved drug other		06/15/2010

Labeler - Wausau Chemical Corporation (006136220)

Establishment
Name	Address	ID/FEI	Operations
Wausau Chemical Corporation		006136220	manufacture

Revised: 06/2010Wausau Chemical Corporation

nebivolol

ne-BIV-oh-lol

Commonly used brand name(s)

In the U.S.

Bystolic

Available Dosage Forms:

Tablet

Therapeutic Class: Antihypertensive

Pharmacologic Class: Beta-Adrenergic Blocker, Cardioselective

Uses For nebivolol

Nebivolol is used alone or together with other medicines to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Nebivolol is a beta-blocker. It works by affecting the response to nerve impulses in certain parts of the body, like the heart. As a result, the heart beats slower and decreases the blood pressure. When the blood pressure is lowered, the amount of blood and oxygen is increased to the heart.

nebivolol is available only with your doctor's prescription.

Before Using nebivolol

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For nebivolol, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to nebivolol or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of nebivolol in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of nebivolol in the elderly.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	C	Animal studies have shown an adverse effect and there are no adequate studies in pregnant women OR no animal studies have been conducted and there are no adequate studies in pregnant women.

Breast Feeding

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking nebivolol, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using nebivolol with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Albuterol

Amiodarone

Arformoterol

Bambuterol

Bitolterol

Broxaterol

Clenbuterol

Clonidine

Colterol

Diltiazem

Dronedarone

Fenoldopam

Fenoterol

Formoterol

Hexoprenaline

Indacaterol

Isoetharine

Levalbuterol

Metaproterenol

Pirbuterol

Procaterol

Reproterol

Rimiterol

Ritodrine

Salmeterol

Terbutaline

Tretoquinol

Tulobuterol

Verapamil

Using nebivolol with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acarbose

Aceclofenac

Acemetacin

Acetohexamide

Alclofenac

Alfuzosin

Amlodipine

Apazone

Arbutamine

Benfluorex

Benoxaprofen

Bromfenac

Bufexamac

Bunazosin

Carprofen

Chlorpropamide

Cimetidine

Clometacin

Clonixin

Dexketoprofen

Diclofenac

Diflunisal

Digoxin

Dipyrone

Doxazosin

Droxicam

Etodolac

Etofenamate

Felbinac

Felodipine

Fenbufen

Fenoprofen

Fentiazac

Floctafenine

Flufenamic Acid

Fluoxetine

Flurbiprofen

Gliclazide

Glimepiride

Glipizide

Gliquidone

Glyburide

Guar Gum

Ibuprofen

Indomethacin

Indoprofen

Insulin

Insulin Aspart, Recombinant

Insulin Glulisine

Insulin Lispro, Recombinant

Isoxicam

Ketoprofen

Ketorolac

Lacidipine

Lercanidipine

Lornoxicam

Manidipine

Meclofenamate

Mefenamic Acid

Meloxicam

Metformin

Mibefradil

Miglitol

Moxisylyte

Nabumetone

Naproxen

Nicardipine

Nifedipine

Niflumic Acid

Nilvadipine

Nimesulide

Nimodipine

Nisoldipine

Nitrendipine

Oxaprozin

Oxyphenbutazone

Phenoxybenzamine

Phentolamine

Phenylbutazone

Pirazolac

Piroxicam

Pirprofen

Pranidipine

Prazosin

Propyphenazone

Proquazone

Repaglinide

Sildenafil

St John's Wort

Sulindac

Suprofen

Tamsulosin

Tenidap

Tenoxicam

Terazosin

Tiaprofenic Acid

Tolazamide

Tolbutamide

Tolmetin

Trimazosin

Troglitazone

Urapidil

Zomepirac

Interactions with Food/Tobacco/Alcohol

Proper Use of nebivolol

In addition to the use of nebivolol, treatment for your high blood pressure may include weight control and changes in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that nebivolol will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

You may take nebivolol with or without food.

Dosing

The dose of nebivolol will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of nebivolol. If your dose is different, do not change it unless your doctor tells you to do so.

For oral dosage form (tablets):
- For high blood pressure:
  - Adults—At first, 5 milligrams (mg) once a day. Your doctor may increase your dose if needed.
  - Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of nebivolol, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using nebivolol

It is very important that your doctor check your progress at regular visits to make sure nebivolol is working properly and to check for unwanted effects.

Do not interrupt or stop using nebivolol without first checking with your doctor. Your doctor may want you to gradually reduce the amount you are using before stopping it completely. Some conditions may become worse when the medicine is stopped suddenly, which can be dangerous.

nebivolol may cause changes in your blood sugar levels. Also, nebivolol may cover up signs of low blood sugar, such as a rapid pulse rate. Check with your doctor if you have these problems or if you notice a change in the results of your blood or urine sugar tests.

Make sure any doctor or dentist who treats you knows that you are using nebivolol. You may need to stop using nebivolol several days before having surgery.

Before you have any medical tests, tell the medical doctor in charge that you are taking nebivolol. The results of some tests may be affected by nebivolol.

nebivolol may cause some people to become less alert than they are normally. If this side effect occurs, do not drive, use machines, or do anything else that could be dangerous if you are not alert while taking nebivolol.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal or vitamin supplements.

nebivolol Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Bloating or swelling of the face, arms, hands, lower legs, or feet

chest pain or discomfort

difficult or labored breathing

lightheadedness, dizziness, or fainting

rapid weight gain

shortness of breath

slow or irregular heartbeat

tightness in the chest

tingling of the hands or feet

unusual tiredness or weakness

unusual weight gain or loss

wheezing

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Absence of or decrease in body movement

anxiety

blue lips, fingernails, or skin

blurred vision

chills

cold sweats

coma

confusion

cool, pale skin

cough

decreased urine output

depression

dilated neck veins

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

dry mouth

extreme fatigue

fast heartbeat

headache

increased hunger

increased sweating

increased thirst

irregular, fast or slow, or shallow breathing

loss of appetite

mood changes

muscle pain or cramps

nausea or vomiting

nervousness

nightmares

noisy breathing

numbness in the hands, feet, or lips

seizures

shakiness

slurred speech

troubled breathing

vomiting

weight gain

More common

Mild headache

Less common

Diarrhea

rash

sleeplessness

trouble sleeping

unable to sleep

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: nebivolol side effects (in more detail)

More nebivolol resources

Nebivolol Side Effects (in more detail)
Nebivolol Dosage
Nebivolol Use in Pregnancy & Breastfeeding
Nebivolol Drug Interactions
Nebivolol Support Group
85 Reviews for Nebivolol - Add your own review/rating

Nebivolol Professional Patient Advice (Wolters Kluwer)

Nebivolol MedFacts Consumer Leaflet (Wolters Kluwer)

Bystolic Prescribing Information (FDA)

Bystolic Monograph (AHFS DI)

Bystolic Consumer Overview

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